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Methamphetamine

Systematic (IUPAC) name
n-methyl-1-phenyl-propan-2-amine
Chemical data
Formula C10H15N
Mol. mass 149.233 g/mol
Synonyms Deoxyephedrine
Pervitin
Anadrex
Metamfetamine
Methylamphetamine
Pharmacokinetic data
Bioavailability 62.7% oral; 79% nasal; 90.3% smoked; 99% rectally; 100% IV
Metabolism Hepatic
Half life 9-15 hours[1]
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(US)
Legal status
Prohibited (S9)(AU) Schedule I(CA) Schedule II(US) Class A(NZ)
Schedule 5(SA)
Injectable:Class A, Oral: A(UK)
Routes Medical: Oral
Recreational: Oral, I.V., I.M., Insufflation, Inhalation, Suppository

Methamphetamine (methylamphetamine or desoxyephedrine), popularly shortened to meth and also nicknamed “ice”, is a psychostimulant and sympathomimetic drug. The dextrorotatory isomer dextromethamphetamine can be prescribed to treat attention-deficit hyperactivity disorder, though unmethylated amphetamine is more commonly prescribed. Also, narcolepsy, and obesity can be treated by the aformentioned isomer under the brand name Desoxyn. It is considered a second line of treatment, used when amphetamine and methylphenidate cause the patient too many side effects. It is only recommended for short term use (~6 weeks) in obesity patients because it is thought that the anoretic effects of the drug are short lived and produce tolerance quickly, whereas the effects on CNS stimulation are much less susceptable to tolerance. It is also used illegally for weight loss and to maintain alertness, focus, motivation, and mental clarity for extended periods of time, and for recreational purposes. “Crystal meth” refers to the crystalline, smokeable form of the drug and is not used for the drug in pill or powdered form.

Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent Methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). Since it stimulates the mesolimbic reward pathway, causing euphoria and excitement, it is prone to abuse and addiction. Users may become obsessed or perform repetitive tasks such as cleaning, hand-washing, or assembling and disassembling objects. Withdrawal is characterized by excessive sleeping, eating and depression-like symptoms, often accompanied by anxiety and drug-craving.[2] Users of methamphetamine often take one or more benzodiazepines as a means of “coming down”.

Contents

* 1 History
o 1.1 World War II
o 1.2 Post war use
o 1.3 Legal restriction in the United States
* 2 Pharmacology
* 3 Illicit production
o 3.1 Synthesis
o 3.2 Production and distribution
* 4 Medical use
o 4.1 d-Methamphetamine
o 4.2 Tolerance
* 5 Effects
o 5.1 Range of effects
o 5.2 Meth mouth
o 5.3 Sexual behaviour
* 6 Addiction
o 6.1 Hygiene
o 6.2 Combating addiction
* 7 Routes of administration
o 7.1 Smoking
o 7.2 Injection
o 7.3 Other methods
* 8 Legality
o 8.1 Australia
o 8.2 Canada
o 8.3 Hong Kong
o 8.4 The Netherlands
o 8.5 New Zealand
o 8.6 South Africa
o 8.7 United Kingdom
o 8.8 United States
o 8.9 Legality of similar chemicals
* 9 See also
* 10 References
* 11 Footnotes
* 12 Documentaries
* 13 External links

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Cops concerned meth labs could spread to this area

SOUTH COUNTY — The discovery of a clandestine methamphetamine laboratory in North Port has area law enforcement officials expressing concern that there could be an increase in the manufacture and abuse of the easily made drug in this area.

Sarasota County Sheriff’s Capt. Don Wampner said police have seen a “tremendous increase” in the manufacture of the drug in Florida’s central counties and are concerned it will spread to this area.

“This was a Nazi lab and that concerns us because they’re so easy to set up,” he said. “You can almost set up one in the back seat of your car.”

He said the labs got their name from the German Nazis in World War II, who developed a simple way to make methamphetamine as a means of keeping their troops going on little or no sleep.

Methamphetamine is a powerful, addictive and unpredictable stimulant.

The arrests

Jason S. French, 30, 5700 block Gallatin Lane, North Port, was arrested and charged with trafficking in methamphetamine and unlawful possession of chemicals. Jason B. Reagan, 31, 5700 block Gallatin Lane, North Port, was arrested and charged with trafficking in methamphetamine, unlawful possession of chemicals and possession of cannabis less than 20 grams.

French and Reagan are being held in the North County Jail on high bonds.

French’s bond is $26,000, Reagan’s bond is $15,000.

French has previous convictions for methamphetamine sales. According to court records, in May 2001 he pleaded no contest to a third-degree felony charge of selling methamphetamine and a second-degree felony charge of attempted trafficking in methamphetamine.

Authorities seized approximately 68 grams — roughly 2.17 pounds — from the lab site. Wampner said the street value was about $7,000.

Under Florida law, conviction on a first-degree felony charge of trafficking a quantity of methamphetamine between 28 and 200 grams carries a minimum of seven years in prison and a $100,000 fine.

Lab site

The incident happened in a secluded section of North Port at Nybert Road and Simburg Street at 12:05 p.m., Dec. 30.

According to the police report, sheriff’s narcotics officers were tipped that French and Reagan were manufacturing and selling methamphetamines. The informant gave officers French’s name, Reagan’s first name and a description of the car, a white 1989 Toyota Cressida, that the men were seen driving.

Officers ran a computer check and learned that French owned the car.

Detectives then searched the secluded Nybert Road/Simburg Street location referred to by the tipster. They spotted the white Toyota, with the windows down and the trunk open, but no one was around it.

During the search for French, officers noticed a small column of white smoke coming up from the wooded area directly across from where the Toyota was parked.

When they investigated, police learned they had discovered an operational methamphetamine laboratory.

A short time later they saw French heading north on Simburg toward Nyberg, walking a dog.

When police questioned him, French said he was just out alone walking his dog and didn’t know where Reagan was.

The officers said French appeared quite nervous when he was questioned.

Man’s best friend?

Thinking Reagan might be nearby, other officers started searching the area again.

They noticed that the dog French had been walking was headed for the corner of Nyberg and Simburg. They followed the pooch and found Reagan hiding in the bushes.

Reagan was sweating, and appeared nervous when police started talking to him.

When they read him his Miranda rights, Reagan said he did not want to talk about it anymore.

Feds involved

The Sarasota Sheriff’s Special Investigations Unit was the lead agency on Monday’s arrests, assisted by the North Port Police Department and the DEA (Drug Enforcement Administration).

DEA sent two agents to the scene.

The agents confirmed local police had found an operational methamphetamine lab and that all the components necessary for the manufacture of methamphetamine, including chemicals, were there.

Wampner said police think the pair had other sites.

“Matter of fact,” he said, “we did find another site within walking distance of the first one.”

Dangerous to make

Due to the potential for explosions from the chemicals used to make methamphetamine, North Port Fire Rescue, the Venice Hazardous Materials Team and the Sarasota County Sheriff’s Office bomb squad also were at the scene.

Wampner said the manufacture of methamphetamine, as well as its use, is extremely dangerous.

“When we got there the chemicals were still smoking,” he said. “So you’ve got all these volatile chemicals and a Bunsen burner.”

Dangerous to use

According to the National Institute on Drug Abuse, methamphetamine is a powerful, addictive stimulant that dramatically affects the central nervous system. The drug is easily made in clandestine labs.

Methamphetamine is commonly known on the street as “speed,” “meth,” “crystal,” “crank” and “glass.”

Direct effects of the drug include decreased appetite, increased activity and a general sense of well-being. The effects of methamphetamine can last six to eight hours. After the initial “rush” there is typically a state of high agitation that in some individuals can lead to unpredictable and violent behavior.

“You can stay awake for three, four days at a time, then crash,” Wampner said, “then get up and do it all over again.”

Wampner said the danger goes up when users start mixing meth with other drugs like alcohol.

Started in California

Methamphetamine abuse began in California and has spread to other areas of the country, including both rural and urban sections of the South and Midwest.

“About 15 years ago, the motorcycle gangs out there started transporting it in the crankcase,” Wampner said. “that’s how it got the name ‘crank.’ ”

According to the 2000 National Household Survey on Drug Abuse, an estimated 8.8 million people have tried methamphetamine at some time in their lives.

There are a few accepted medical uses of methamphetamine, such as the treatment of narcolepsy, attention deficit disorder and — for short term use — obesity.

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facts about marijuana

Marijuana is the most often used illegal drug in this country.

As the number of people who use marijuana has increased, the number who view the drug as harmful has decreased. Among those surveyed in 2001, current marijuana use has increased by about 62 percent since 1991. The proportion of those who believe regular use of marijuana is harmful has dropped by about 27 percent since 1991.

Researchers are examining the possibility that long-term marijuana use may create changes in the brain that make a person more at risk of becoming addicted to other drugs, such as alcohol or cocaine .

Marijuana is derived from the cannabis plant and grows in many countries, including the United States. People have been known to put it in rolling papers to make marijuana cigarettes, smoke it in bongs or pipes, or mix it in baked goods or tea and eat or drink it. The cannabis plant also yields hashish, a stronger form of marijuana, and hash oil, the strongest form that has very high levels of THC, the psychoactive ingredient in cannabis.

Marijuana is a green, brown, or gray mixture of dried, shredded leaves, stems, seeds, and flowers of the hemp plant (Cannabis sativa). Before the 1960s, many Americans had never heard of marijuana.

Cannabis is a term that refers to marijuana and other drugs made from the same plant. Strong forms of cannabis include sinse-milla (sin-seh-me-yah), hashish (”hash” for short), and hash oil.

All forms of cannabis are mind-altering (psychoactive) drugs; they all contain THC (delta-9-tetrahydrocannabinol), the main active chemical in marijuana. They also contain more than 400 other chemicals.

The effect of Marijuana on the user depends on the strength or potency of the THC it contains. THC potency has increased since the 1970s but has been about the same since the mid-1980s. The strength of the drug is measured by the average amount of THC in test samples confiscated by law enforcement agencies.

Most ordinary marijuana has an average of 3 percent THC, Sinsemilla (made from just the buds and flowering tops of female plants) has an average of 7.5 percent THC, with a range as high as 24 percent, Hashish (the sticky resin from the female plant flowers) has an average of 3.6 percent, with a range as high as 28 percent, Hash oil, a tar-like liquid distilled from hashish, has an average of 16 percent, with a range as high as 43 percent.

HOW IT IS USED

Most users roll loose marijuana into a cigarette (called a joint or a nail) or smoke it in a pipe. One well-known type of water pipe is the bong. Some users mix marijuana into foods or use it to brew a tea. Another method is to slice open a cigar and replace the tobacco with marijuana, making what’s called a blunt. When the blunt is smoked with a 40 oz. bottle of malt liquor, it is called a “B-40.”

Lately, marijuana cigarettes or blunts often include crack cocaine, a combination known by various street names, such as “primos” or “woolies.” Joints and blunts often are dipped in PCP and are called “happy sticks,” “wicky sticks,” “love boat,” or “tical.”

STREET NAMES

Aunt Mary, skunk, boom, gangster, kif, or ganja,Texas tea, Maui wowie, and Chronic. A recent book of American slang lists more than 200 terms for various kids of marijuana.

EFFECTS

Marijuana contains chemicals that act on the marijuana receptor in the brain. Scientists have recently identified the natural chemical, anandamide, designed to fit the marijuana receptor. While scientists do not know all of the drug’s effects, several studies have established that marijuana interferes with memory and learning. A new study confirms that heavy (daily) marijuana use impairs critical skills related to attention, memory and learning. In this study, “Heavy users could not pay attention to the material well enough to register the information in the first place so that it could be recalled and repeated later,” say the researchers in the Journal of the American Medical Association (2/21/96).

These deficits persisted up to 24 hours after users stopped feeling high. Marijuana also impairs judgment and reaction time. A special study showed that one-third of drivers stopped for reckless driving were high on marijuana. Another study revealed that of drivers involved in accidents who were treated at a trauma center, 15 percent had been smoking marijuana. Daily use of from 1 to 3 marijuana cigarettes appears to produce the same lung damage and cancer risk as smoking 5 times as many cigarettes. Finally, researchers have found for the first time that marijuana can cause withdrawal symptoms in laboratory animals, and that marijuana acts on the brain and nervous system as do other addictive drugs.

Marijuana affects many skills required for safe driving: alertness, the ability to concentrate, coordination, and reaction time. These effects can last up to 24 hours after smoking marijuana. Marijuana use can make it difficult to judge distances and react to signals and sounds on the road.

There are data showing that marijuana can play a role in crashes. When users combine marijuana with alcohol, as they often do, the hazards of driving can be more severe than with either drug alone.

A study of patients in a shock-trauma unit who had been in traffic accidents revealed that 15 percent of those who had been driving a car or motorcycle had been smoking marijuana, and another 17 percent had both THC and alcohol in their blood.

MARIJUANA USE AND MENTAL HEALTH

High doses of marijuana can induce psychosis (disturbed perceptions and thoughts), and marijuana use can worsen psychotic symptoms in people who have schizophrenia. There is also evidence of increased rates of depression, anxiety, and suicidal thinking in chronic marijuana users. However, it is not yet clear whether marijuana is being used in an attempt to self-medicate an already present but otherwise untreated mental health problem, or whether marijuana use leads to mental disorders (or both).

MARIJUANA AND PREGNANCY

Doctors advise pregnant women not to use any drugs because they might harm the growing fetus. One animal study has linked marijuana use to loss of the fetus very early in pregnancy.

Some scientific studies have found that babies born to women who used marijuana during their pregnancy display altered responses to visual stimulation, increased tremors, and a high pitched cry, which may indicate problems with nervous system development. During pre- and early school years, marijuana-exposed children have been reported to have more behavioral problems and difficulties with sustained attention and memory than no exposed children

Researchers are not certain whether any effects of marijuana during pregnancy persist as the child grows up; however, because some parts of the brain continue to develop into adolescence, it is also possible that certain kinds of problems will become more evident as the child matures.

When a nursing mother uses marijuana, some of the THC is passed to the baby in her breast milk. This is a matter for concern, since the THC in the mother’s milk is much more concentrated than that in the mother’s blood. One study has shown that the use of marijuana by a mother during the first month of breastfeeding can impair the infant’s motor development (control of muscle movement).

While all of the long-term effects of marijuana use are not yet known, there are studies showing serious health concerns. For example, a group of scientists in California examined the health status of 450 daily smokers of marijuana but not tobacco. They found that the marijuana smokers had more sick days and more doctor visits for respiratory problems and other types of illness than did a similar group who did not smoke either substance .

Findings so far show that the regular use of marijuana or THC may play a role in cancer and problems in the respiratory, and immune systems.

MARIJUANA USE AND CANCER
It is hard to find out whether marijuana alone causes cancer because many people who smoke marijuana also smoke cigarettes and use other drugs. Marijuana smoke contains some of the same cancer-causing compounds as tobacco, sometimes in higher concentrations. Studies show that someone who smokes five joints per day may be taking in as many cancer-causing chemicals as someone who smokes a full pack of cigarettes every day. Marijuana smoking could contribute to early development of head and neck cancer in some people.

MARIJUANA USAGE AND THE IMMUNE SYSTEM
Our immune system protects the body from many agents that cause disease. It is not certain whether marijuana damages the immune system of people. But both animal and human studies have shown that marijuana impairs the ability of T-cells in the lungs’ immune defense system to fight off some infections.

MARIJUANA USE AND LUNG AND AIRWAYS

People who smoke marijuana regularly may develop many of the same breathing problems that tobacco smokers have, such as daily cough and phlegm production, more frequent chest colds, a heightened risk of lung infections, and a greater tendency toward obstructed airways. Cancer of the respiratory tract and lungs may also be promoted by marijuana smoke, since it contains irritants and carcinogens. Marijuana smokers usually inhale more deeply and hold their breath longer, which increases the lungs’ exposure to carcinogenic smoke. Smoking marijuana may increase the risk of cancer more than smoking tobacco does.

Some frequent, long-term marijuana users show signs of a lack of motivation (amotivational syndrome). Their problems include not caring about what happens in their lives, no desire to work regularly, fatigue, and a lack of concern about how they look. As a result of these symptoms, some users tend to perform poorly in school or at work. Scientists are still studying these problems.

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Marijuana plants require a minimum of eight hours of sunlight per day and should be planted in late April/early May, after the last frost of the year. Growing an outdoor marijuana crop has been the favored method over the years, because marijuana seems to grow better without as much attention when in its natural habitat.

Growing marijuana outdoors requires precautions not encountered with an indoors crop; you must be able to avoid detection, both from law enforcement freaks and common freaks, both of whom will take your weed and probably use it. Of course, one will also arrest you. You must also have access to the area to prepare the soil and harvest the crop. There are two schools of thought about starting the marijuana seeds. One says you should start the seedlings for about ten days in an indoor starter box (see the indoor section) and then transplant. The other theory is that you should just start them in the correct location. Fewer plants will come up with this method, but there is no shock of transplant to kill some of the seedlings halfway through.

The soil should be prepared for the little devils by turning it over a couple of times and adding about one cup of hydrated lime per square yard of soil and a little bit (not too much, now) of good water soluble nitrogen fertilizer. The soil should now be watered several times and left to sit about one week.

The plants should be planted at least three feet apart, getting too greedy and stacking them too close will result in stunted plants. The plants like some water during their growing season, BUT not too much. This is especially true around the roots, as too much water will rot the root system.

Grass grows well in corn or hops, and these plants will help provide some camouflage. It does not grow well with rye, or spinach It is probably a good idea to plant in many small, broken patches, as people tend to notice patterns.

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A private San Francisco area university dedicated to the study of the cannabis industry is giving a whole new meaning to higher education.

At Oaksterdam University — so called after the nickname locals have given to Oakland — students learn how to grow, harvest and cook marijuana, as well as dispense it to others.

The goal, say administrators, is to educate consumers about the benefits of the mind-altering plant and encourage graduates to start their own dispensaries in California, even though possession remains prohibited under federal law.

The university, which is modeled on a similar school in Amsterdam, opened in November and has recently begun offering classes in Los Angeles.

On a recent day, a group of students gathered in a former pharmacy in downtown Oakland for a class that included topics such as the politics of marijuana, horticulture and bud tending.

Bikers with ponytails and tattoos sat next to speckled middle-aged women and took notes as a series of lecturers spoke about the history of the drug.

Later, students took part in role plays about what to do if stopped by a police officer and then learned about pH balancing, drying, curing and smell abatement.

At the end of the weekend-long intensive course, students took a test, which if passed, would give them a certificate they could use to get a job at a marijuana dispensary.

So far 200 students have graduated and over 500 people have enrolled at the private university.

Among the current students is 56-year-old Christie, a freelance website producer who declined to give her last name.

She said she came to Oaksterdam to educate herself about the ever-changing laws surrounding marijuana, especially since the federal Drug Enforcement Administration sent out letters to dispensaries late last year, urging them to close shop or, else, face fines.

“The federal intervention is a little scary, so I really want to understand all the legal aspects,” said Christie.

Diagnosed with depression, she took Prozac for several years, but said that it left her feeling manic and nauseous.

Then her son turned her on to marijuana and she soon felt better. Today, Christie is off the anti-depressants and says her life has improved significantly.

“I just feel more joy and can finally sleep better,” she said.

Oaksterdam staff insist marijuana helps alleviate pain in people suffering debilitating illnesses including cancer, multiple sclerosis and HIV/AIDS.

They also say legalizing the drug creates legitimacy for the widely used substance and boosts tax revenue for the state.

“The government spends an astronomical amount of money on drug enforcement and putting people in jail,” said Danielle Schumacher, chancellor of Oaksterdam University.

“When the DEA raids dispensaries and seizes their assets, they are actually taking away California’s revenue base.”

California legalized the use of medical marijuana in 1996, a law that has been broadened in recent years to protect those who produce, provide or sell the substance for medical purposes and creating a voluntary identification program.

But seizures of dispensaries by the federal Drug Enforcement Administration have continued and in 2006, San Diego County filed a lawsuit against the state to overturn the medical marijuana law.

Not surprisingly, the creation of Oaksterdam University has not been greeted warmly by the DEA, which says the school sends the wrong message in the country’s fight against drugs and promotes criminal activity.

“It reinforces a very complacent attitude by the public that marijuana is safe and effective, when it’s not,” said Michael Chapman, an assistant special agent in DEA’s San Francisco office.

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