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Methamphetamine

Systematic (IUPAC) name
n-methyl-1-phenyl-propan-2-amine
Chemical data
Formula C10H15N
Mol. mass 149.233 g/mol
Synonyms Deoxyephedrine
Pervitin
Anadrex
Metamfetamine
Methylamphetamine
Pharmacokinetic data
Bioavailability 62.7% oral; 79% nasal; 90.3% smoked; 99% rectally; 100% IV
Metabolism Hepatic
Half life 9-15 hours[1]
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(US)
Legal status
Prohibited (S9)(AU) Schedule I(CA) Schedule II(US) Class A(NZ)
Schedule 5(SA)
Injectable:Class A, Oral: A(UK)
Routes Medical: Oral
Recreational: Oral, I.V., I.M., Insufflation, Inhalation, Suppository

Methamphetamine (methylamphetamine or desoxyephedrine), popularly shortened to meth and also nicknamed “ice”, is a psychostimulant and sympathomimetic drug. The dextrorotatory isomer dextromethamphetamine can be prescribed to treat attention-deficit hyperactivity disorder, though unmethylated amphetamine is more commonly prescribed. Also, narcolepsy, and obesity can be treated by the aformentioned isomer under the brand name Desoxyn. It is considered a second line of treatment, used when amphetamine and methylphenidate cause the patient too many side effects. It is only recommended for short term use (~6 weeks) in obesity patients because it is thought that the anoretic effects of the drug are short lived and produce tolerance quickly, whereas the effects on CNS stimulation are much less susceptable to tolerance. It is also used illegally for weight loss and to maintain alertness, focus, motivation, and mental clarity for extended periods of time, and for recreational purposes. “Crystal meth” refers to the crystalline, smokeable form of the drug and is not used for the drug in pill or powdered form.

Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent Methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). Since it stimulates the mesolimbic reward pathway, causing euphoria and excitement, it is prone to abuse and addiction. Users may become obsessed or perform repetitive tasks such as cleaning, hand-washing, or assembling and disassembling objects. Withdrawal is characterized by excessive sleeping, eating and depression-like symptoms, often accompanied by anxiety and drug-craving.[2] Users of methamphetamine often take one or more benzodiazepines as a means of “coming down”.

Contents

* 1 History
o 1.1 World War II
o 1.2 Post war use
o 1.3 Legal restriction in the United States
* 2 Pharmacology
* 3 Illicit production
o 3.1 Synthesis
o 3.2 Production and distribution
* 4 Medical use
o 4.1 d-Methamphetamine
o 4.2 Tolerance
* 5 Effects
o 5.1 Range of effects
o 5.2 Meth mouth
o 5.3 Sexual behaviour
* 6 Addiction
o 6.1 Hygiene
o 6.2 Combating addiction
* 7 Routes of administration
o 7.1 Smoking
o 7.2 Injection
o 7.3 Other methods
* 8 Legality
o 8.1 Australia
o 8.2 Canada
o 8.3 Hong Kong
o 8.4 The Netherlands
o 8.5 New Zealand
o 8.6 South Africa
o 8.7 United Kingdom
o 8.8 United States
o 8.9 Legality of similar chemicals
* 9 See also
* 10 References
* 11 Footnotes
* 12 Documentaries
* 13 External links

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Cops concerned meth labs could spread to this area

SOUTH COUNTY — The discovery of a clandestine methamphetamine laboratory in North Port has area law enforcement officials expressing concern that there could be an increase in the manufacture and abuse of the easily made drug in this area.

Sarasota County Sheriff’s Capt. Don Wampner said police have seen a “tremendous increase” in the manufacture of the drug in Florida’s central counties and are concerned it will spread to this area.

“This was a Nazi lab and that concerns us because they’re so easy to set up,” he said. “You can almost set up one in the back seat of your car.”

He said the labs got their name from the German Nazis in World War II, who developed a simple way to make methamphetamine as a means of keeping their troops going on little or no sleep.

Methamphetamine is a powerful, addictive and unpredictable stimulant.

The arrests

Jason S. French, 30, 5700 block Gallatin Lane, North Port, was arrested and charged with trafficking in methamphetamine and unlawful possession of chemicals. Jason B. Reagan, 31, 5700 block Gallatin Lane, North Port, was arrested and charged with trafficking in methamphetamine, unlawful possession of chemicals and possession of cannabis less than 20 grams.

French and Reagan are being held in the North County Jail on high bonds.

French’s bond is $26,000, Reagan’s bond is $15,000.

French has previous convictions for methamphetamine sales. According to court records, in May 2001 he pleaded no contest to a third-degree felony charge of selling methamphetamine and a second-degree felony charge of attempted trafficking in methamphetamine.

Authorities seized approximately 68 grams — roughly 2.17 pounds — from the lab site. Wampner said the street value was about $7,000.

Under Florida law, conviction on a first-degree felony charge of trafficking a quantity of methamphetamine between 28 and 200 grams carries a minimum of seven years in prison and a $100,000 fine.

Lab site

The incident happened in a secluded section of North Port at Nybert Road and Simburg Street at 12:05 p.m., Dec. 30.

According to the police report, sheriff’s narcotics officers were tipped that French and Reagan were manufacturing and selling methamphetamines. The informant gave officers French’s name, Reagan’s first name and a description of the car, a white 1989 Toyota Cressida, that the men were seen driving.

Officers ran a computer check and learned that French owned the car.

Detectives then searched the secluded Nybert Road/Simburg Street location referred to by the tipster. They spotted the white Toyota, with the windows down and the trunk open, but no one was around it.

During the search for French, officers noticed a small column of white smoke coming up from the wooded area directly across from where the Toyota was parked.

When they investigated, police learned they had discovered an operational methamphetamine laboratory.

A short time later they saw French heading north on Simburg toward Nyberg, walking a dog.

When police questioned him, French said he was just out alone walking his dog and didn’t know where Reagan was.

The officers said French appeared quite nervous when he was questioned.

Man’s best friend?

Thinking Reagan might be nearby, other officers started searching the area again.

They noticed that the dog French had been walking was headed for the corner of Nyberg and Simburg. They followed the pooch and found Reagan hiding in the bushes.

Reagan was sweating, and appeared nervous when police started talking to him.

When they read him his Miranda rights, Reagan said he did not want to talk about it anymore.

Feds involved

The Sarasota Sheriff’s Special Investigations Unit was the lead agency on Monday’s arrests, assisted by the North Port Police Department and the DEA (Drug Enforcement Administration).

DEA sent two agents to the scene.

The agents confirmed local police had found an operational methamphetamine lab and that all the components necessary for the manufacture of methamphetamine, including chemicals, were there.

Wampner said police think the pair had other sites.

“Matter of fact,” he said, “we did find another site within walking distance of the first one.”

Dangerous to make

Due to the potential for explosions from the chemicals used to make methamphetamine, North Port Fire Rescue, the Venice Hazardous Materials Team and the Sarasota County Sheriff’s Office bomb squad also were at the scene.

Wampner said the manufacture of methamphetamine, as well as its use, is extremely dangerous.

“When we got there the chemicals were still smoking,” he said. “So you’ve got all these volatile chemicals and a Bunsen burner.”

Dangerous to use

According to the National Institute on Drug Abuse, methamphetamine is a powerful, addictive stimulant that dramatically affects the central nervous system. The drug is easily made in clandestine labs.

Methamphetamine is commonly known on the street as “speed,” “meth,” “crystal,” “crank” and “glass.”

Direct effects of the drug include decreased appetite, increased activity and a general sense of well-being. The effects of methamphetamine can last six to eight hours. After the initial “rush” there is typically a state of high agitation that in some individuals can lead to unpredictable and violent behavior.

“You can stay awake for three, four days at a time, then crash,” Wampner said, “then get up and do it all over again.”

Wampner said the danger goes up when users start mixing meth with other drugs like alcohol.

Started in California

Methamphetamine abuse began in California and has spread to other areas of the country, including both rural and urban sections of the South and Midwest.

“About 15 years ago, the motorcycle gangs out there started transporting it in the crankcase,” Wampner said. “that’s how it got the name ‘crank.’ ”

According to the 2000 National Household Survey on Drug Abuse, an estimated 8.8 million people have tried methamphetamine at some time in their lives.

There are a few accepted medical uses of methamphetamine, such as the treatment of narcolepsy, attention deficit disorder and — for short term use — obesity.

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